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A leading researcher into the potential side effects of Avandia says that he was threatened by the company which manufacturers the diabetes drug. Dr. John Buse testified before a congressional committee that Dr. Tadataka Yamada, an executive with GlaxoSmithKline, made “disturbing” comments to him after Dr. Buse raised questions about the risk of Avandia side effects.
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A leading member of the U.S. Senate says that a diabetes expert who was asked to review a controversial study on the risk of Avandia side effects leaked its findings to the drug’s manufacturer, GlaxoSmithKline.
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Two U.S. pharmacy benefits managers have announced that they have dropped Avandia from the list of drugs they carry due to concerns about the side effects of the drug. Studies have linked Avandia to an increased risk of heart attack, congestive heart failure, osteoporosis and other conditions.
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A new study has found that reports of Avandia side effects to the Food and Drug Administration tripled in the month after the publication of an article detailing the heart risks of the drug. Experts say that the increase in reported cases of Avandia side effects is probably due to a greater awareness among doctors that the drug can lead to heart problems. The reports included cases of side effects among patients taking both Avandia and Avandamet, which contains the same active ingredient, rosiglitazone.
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The diabetes drug Avandia was the key topic of conversation at a recent meeting in Chicago of experts on the disease. The session at the annual meeting of the American Diabetes Association was scheduled in order to discuss a recent study in the New England Journal of Medicine, which found that Avandia could increase a patient’s risk of death by 64% and of heart attack by 43%.
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